Data Library

The data library contains a number of pharmacokinetic and pharamcodynamic datasets of chi, kindly provided by the authors of the referenced publications.

Functional classes

• DataLibrary

Detailed API

class chi.library.DataLibrary

A collection of Erlotinib PKPD datasets.

Each method corresponds to a separate dataset, which will return the corresponding dataset in form of a pandas.DataFrame.

All dataset are organised in 9 columns: ID | Time | Time unit | Observable | Value | Observable unit | Dose | Dose unit | Duration.

References

[1] (1,2,3,4,5)

Eigenmann, M. J. et al., Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib, Mol Cancer Ther. 2016; 15(12):3110-3119.

lung_cancer_control_group()

Returns the lung cancer control group data published in [1] as a pandas.DataFrame.

The dataset contains the time series data of 8 mice with patient-derived lung cancer implants. The tumour volume of each mouse was monitored over a period of 30 days and measured a couple times a week.

lung_cancer_high_erlotinib_dose_group()

Returns the high erlotinib dose lung cancer treatment group data published in [1] as a pandas.DataFrame.

The dataset contains the time series data of 6 mice with patient-derived lung cancer implants. Each mouse was treated with an oral dose of erlotinib of \(100\, \text{mg}\) per \(\text{g}\) body weight. The dose was administered daily from day 3 to day 16, with a treatment break on days 9 to 13.

The blood plasma concentration of erlotinib was measured on day 14, while the tumour volume of each mouse was monitored over a period of 30 days and measured a couple times a week.

lung_cancer_low_erlotinib_dose_group()

Returns the low erlotinib dose lung cancer treatment group data published in [1] as a pandas.DataFrame.

The dataset contains the time series data of 8 mice with patient-derived lung cancer implants. Each mouse was treated with an oral dose of erlotinib of \(6.25\, \text{mg}\) per \(\text{g}\) body weight. The dose was administered daily from day 3 to day 16.

The blood plasma concentration of erlotinib was measured on day 10 and 16, while the tumour volume of each mouse was monitored over a period of 30 days and measured a couple times a week.

lung_cancer_medium_erlotinib_dose_group()

Returns the medium erlotinib dose lung cancer treatment group data published in [1] as a pandas.DataFrame.

The dataset contains the time series data of 8 mice with patient-derived lung cancer implants. Each mouse was treated with an oral dose of erlotinib of \(25\, \text{mg}\) per \(\text{g}\) body weight. The dose was administered daily from day 3 to day 16.

The blood plasma concentration of erlotinib was measured on day 10 and 16, while the tumour volume of each mouse was monitored over a period of 30 days and measured a couple times a week.

lung_cancer_single_erlotinib_dose_group()

Returns the single erlotinib dose lung cancer treatment group data published in [1] as a pandas.DataFrame.

The dataset contains the time series data of 30 mice with patient-derived lung cancer implants. Each mouse was treated with a single oral dose of erlotinib of \(100\, \text{mg}\) per \(\text{g}\) body weight. The dose was administered either on day 0 or day 4.

The blood plasma concentration of erlotinib was measured only once per mouse, either on day 0 or day 4.